The first asymmetric total synthesis of (+)-coriandrone A and B.
نویسندگان
چکیده
The first enantioselective total synthesis of (+)-coriandrone A and B, two bioactive natural products, has been achieved in 10 steps and 11 steps starting from commercially available methyl 2-hydroxy-4-methoxybenzoate. Key reactions include a Claison rearrangement, a Shi-type epoxidation-cyclization sequence and ortho-metallation of t-butylbenzamides with (S)-(-)-propylene oxide reaction.
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ورودعنوان ژورنال:
- Organic & biomolecular chemistry
دوره 11 39 شماره
صفحات -
تاریخ انتشار 2013